Haldimand police and emergency services responded to a two-vehicle collision on Haldimand Road 32 at Concession 2 Road around noon Friday.
One individual was pronounced deceased at the scene and has been identified as Nancy Fleming, 67, of Hamilton.
OPP Technical Collision Investigators (TCI) attended the scene and are assisting with the investigation. The intersection was closed for several hours.
OPP is asking anyone who may have witnessed the collision, or who may have any information, to contact them at 1-888-310-1122.